![]() ![]() ![]() ![]() ![]() INJECTABLES: Use double chemotherapy gloves and a protective gown. Observe and exercise appropriate precautions for handling, preparation, administration, and disposal of hazardous drugs. Many estradiol products have been FDA-approved since the 1990's, in accordance with the FDA's guidance to provide efficacious low-dose estrogen therapies in alternate drug delivery systems.įor storage information, see the specific product information within the How Supplied section. Vaginal therapies are preferred in postmenopausal women with exclusive genitourinary symptoms, due to lower systemic absorption/exposure with most of these dosage forms. Estradiol is available in many dosage forms, including oral tablets, transdermal systems, topical emulsions, topical gels, topical sprays, vaginal creams, vaginal rings, and parenteral depot injections. Various estrogen products have been marketed in the U.S. Estradiol is primarily used to prevent osteoporosis and relieve vasomotor and genitourinary symptoms associated with menopause (natural or surgical), for postmenopausal osteoporosis prevention, and is also used to treat female hypogonadism and other abnormalities of female gonadotropin dysfunction. Esterification of estradiol to estradiol cypionate or valerate increases the parenteral duration of action of estradiol to allow for parenteral intramuscular administration. Due to almost complete first-pass metabolism, estradiol must be given in a micronized oral dosage form to ensure therapeutic effect. There is no evidence that 'natural' estrogens are more or less efficacious or safe than 'synthetic' estrogens. Estradiol can be obtained from natural sources or prepared synthetically. Estradiol is the principal intracellular human estrogen and is substantially more active than its metabolites, estrone and estriol, at the cellular level. ![]()
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